A lavish dramatisation following the infamous Borgia family's ruthless grip on power in Renaissance Italy, centring on Rodrigo Borgia's rise to become Pope Alexander VI and the scheming ambitions of his children, including the cunning Cesare and the enigmatic Lucrezia. The series explores the corruption, political manipulation, and moral compromise that defined the family's reign at the heart of the Catholic Church. Betrayal, murder, and dynastic survival thread through the story as the Borgias struggle to maintain their dominance against rival noble families and the shifting loyalties of those around them.